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Thread: Pramipexole

  1. #1
    ydrohoos is offline Junior Member ydrohoos is on a distinguished road
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    Default Pramipexole

    Ok, i have started pramipexole 0.5mg a day.

    Pramipexole is a dopamine agonist that is reported to help with libido as well as erections. Flavio has tried cabergoline which is a similar drug but his feedback was not positive.

    Pramipexole so far seems that it has worked fairly well. I feel that my libido has increased but the side effects are pretty strong. It makes me feel quite sleepy and weak. The sleep is not great either. I toss and turn quite a lot during the night.

    I am hoping that sides will subside as soon as my body gets used to the drug.


    I will keep you updated.

  2. #2
    Flavio is offline Senior Member Flavio is on a distinguished road
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    Quote Originally Posted by ydrohoos View Post
    Ok, i have started pramipexole 0.5mg a day.

    Pramipexole is a dopamine agonist that is reported to help with libido as well as erections. Flavio has tried cabergoline which is a similar drug but his feedback was not positive.

    [...]

    Great tip, thanks.

    A couple of years ago, there was another dopamine agonist that was licensed in Europe for the treatment of ED: apomorphine (brand name Uprima). Unfortunately, it was discontinued for commercial reasons.

    I suggest you also try VIGAMED (oral phentolamine 40mg). VIGAMED is not an experimental drug, it is a licensed ED treatment in South America and there are several studies that show its safety and efficacy. Because it blocks the negative effects of stress hormones via the sympathetic system, VIGAMED may be a good solution for cases of sexual performance anxiety.

    VIGAMED is not available in Europe but there are several online pharmacies that sell it. I suggest you try one of these:

    vasomaxclinic.com

    propecia-proscar.com

  3. #3
    ydrohoos is offline Junior Member ydrohoos is on a distinguished road
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    A quick update

    I am now on 1mg pramipexole.
    My observation is that it does increase libido but mostly for about two hours after taking it. I cannot say with confidence wether it has an effect throughout the day. I would prefer something stronger.

    The sides have in most part dissapeared. Not feeling as drowsy as before.

    Details of how the drug works can be found on wikipedia.

    Pramipexole - Wikipedia, the free encyclopedia

    Sorry for not being very active but i have split up with my partner of 9 years and this has hurt me quite a lot. I was about to leave the uk and go and live with her and then she broke the news that she has found someone else. Crazy !!!

    A month ago i had told her to split up because i was not sure if i wanted to be with her anymore but she begged me not to leave her. I thought to myself that i loved her too much to do this to her so i accepted to continue together.
    Then i made my preparations to relocate to Cyprus and i was meant to leave the UK on the 19th of October. Last week she informed me about the new man in her life. She cut me off facebook, she does not reply to emails and never answers her phone. Very nice of her...
    I would have never treated her that way even if i had made a decission to leave her. I would have been there for her; and i am being honest. The girl has been very nice with me and i have no complaints about the way she has been treating me over the years. I used to trust her more than anyone. I really thought that she could do anything for me. Over the years i was always the one giving and showing less love. Suddenly a switch flicked and she does not even want to hear my voice.

    Current status: no woman, no job, no home (i have to leave the house within ten days)

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    Flavio is offline Senior Member Flavio is on a distinguished road
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    Quote Originally Posted by ydrohoos View Post
    A quick update

    I am now on 1mg pramipexole.
    My observation is that it does increase libido but mostly for about two hours after taking it. I cannot say with confidence wether it has an effect throughout the day. I would prefer something stronger.

    The sides have in most part dissapeared. Not feeling as drowsy as before.
    This is strange. A dopamine agonist that makes you feel drowsy? Shouldn't dopamine have the opposite effect (i.e. improve mood and alertness)?

  5. #5
    ydrohoos is offline Junior Member ydrohoos is on a distinguished road
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    Strange indeed but for some reason it does make you quite weary and drowsy. The funny thing is that you cannot sleep very well either. For the first few days i was tossing and turning most of the night. The sleep was quite strange. If you have a look at its side effects you will see that sleepeness is the most commonly occuring one. I cannot expalin how this happens exactly, you will have to look into the pharmacology details.
    At the moment however i feel that all the side effects have subsided to the point that are bearly noticable.

    A few more points:
    Pramipexole is used by bodybuilders quite a lot because its dopamine enhancing properties reduce prolactin (an eostrogen) levels which may elevate due to the use of certain steroid drugs. Prolactin excess can cause gynecomastia (man boobs) and it is also responsible for sexual satiety. As a result high prolactin levels can have a detrimental effect on libido.

    NOw, a reduction of estrogen in the body, indirectly raises the levels of circulating testosterone which is a good thing for sex drive and other sexual parameters such as sperm count.
    In addition dopamine itself has a prosexual effect and it can raise libido. Cocaine for example which acts on the dopamine receptors has a prosexual effect too.

    This is more or less how pramipexole can have a positive effect on libido as well as erctile function.

    It is not a bad drug in my opinion but you have to start at a low dose and increase it slowly otherwise the side effects will be more pronounced.

  6. #6
    Flavio is offline Senior Member Flavio is on a distinguished road
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    Quote Originally Posted by ydrohoos View Post
    [...] Pramipexole is used by bodybuilders quite a lot because its dopamine enhancing properties reduce prolactin (an eostrogen) levels which may elevate due to the use of certain steroid drugs. Prolactin excess can cause gynecomastia (man boobs) and it is also responsible for sexual satiety. As a result high prolactin levels can have a detrimental effect on libido.

    NOw, a reduction of estrogen in the body, indirectly raises the levels of circulating testosterone which is a good thing for sex drive and other sexual parameters such as sperm count. [...]
    Interesting.

    So, basically, you're saying that a dopaminergic agent may indirectly increase testosterone levels. I remember reading something similar about cabergoline. Do you think apomorphine can have the same effect?

    I'm a bit worried because raising testosterone isn't always a good thing. I'm trying to preserve my hair from male pattern baldness (I've been taking finasteride, an androgen blocker, for the last 13 years) and raising testosterone could have drastic effects. All the ED treatments that I'm currently taking (Vigamed, Cialis, Prelox) have had excellent results but, as far as know, none of them increases testosterone.

    And another thing: you mentioned that pramipexole improved your libido, which is obviously a good thing. But does it actually improve your erections, like Cialis and Vigamed do?

  7. #7
    ydrohoos is offline Junior Member ydrohoos is on a distinguished road
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    Flavio i don't think that using finasteride is a great idea when you have some slight performance anxiety or libio issues. It has been widely documented it can actuallt cause these symptoms. If i was you i would look into alternatives. Minoxidil i believe has milder side efects.

    Regarding the effect of prami on T, as a i said it is not direct. It comes form supressign prolactin levels which as an estrogen inhibits testerone production.

    Regarding the erections it is a bit difficult to say because mine are quite firm and i cannot tell with certainty what effect exactly prami exerts. However kowing that apomorphine (another dopamine agonist) has been used for the treatment of ED i would expect that prami too has a positive effect on erections; albeit not as viagra, cialis, etc

    Also, as you have probably already (on wiki) read it is used for the treatment of ED and loss of libido to patients treated with SSRIs - a category of anti depressants notorious for causing sexual side effects.

    Below a relevant link (not of the best websites)

    Dopamine agonists - bromocriptine, pergolide, pramipexole, lisuride, apomorphine

    A kind of funny article that demonstrates the prosexual effects of dopamine agonists. They can actually cause hypersexuality.

    Pathological Hypersexuality Induced by Dopamine Replacement Therapy in a Patient with Progressive Supranuclear Palsy -- Kim et al. 20 (4): 496 -- J Neuropsychiatry Clin Neurosci

    There is more in the internet about dopamine agonists in relation to libido but not as much in relation to erectile function. My opinionis is that these drugs can help psychogenic as well as physiogenic ED.
    In my theory, when you suffer from psychogenic ed it is likely that the circualtion of dopamine is negatively affected by the secreation of stress hormones while you are on the act. Aiding the production of dopamine should definitely have a beneficial effect.


    Below an interesting video. There are some more in the same series regarding sex.

    Science of Sex Appeal: Testosterone vs. Dopamine : Video : Discovery Channel

    One more link

    Dopamine and male sexual function

    I didnt have much time to find very good links but of you do some reserch on the web you find quite a lot regarding dopamine agonists and sex.

  8. #8
    ydrohoos is offline Junior Member ydrohoos is on a distinguished road
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    Did i mention the ejaculation ?

    I will have to be careful next time i am with a girl because shooting my load while on pramipexole is dangerous

    I don't want to destroy anyones eye sight by accident; that would be cruel. I just want to be able to have good sex.

    We are talking about double the force and significantly increased volume.

    Plus, reduced refractory period due to the suppression of prolactin.

    From now on you can call me

    Sex Pistol

    One more thing - using it on demand (rather than using it daily) should also be quite effective. First time i had a pill i got very horny within 30 mins.

    I forgot to mention in my previous posts that it is generally a quite powerful drug and you should make sure that you won't have any health issues that may be aggrevated by its use.

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