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Thread: Bremelanotide (PT 141) could be out saviour

  1. #1
    ydrohoos is offline Junior Member ydrohoos is on a distinguished road
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    Default Bremelanotide (PT 141) could be out saviour

    Hello guys

    I am very glad to have found this forum. There is so much useful information in here and i can now see there are people with similar problems to mine.

    I am 29 and my ED is psychogenic.

    I will post some more things bout my background and experiences soon.

    For now i would like to live you with some very encouraging news about a very promising sounding treatment.

    Dear honourable gentlemen i would like to present BREMELANOTIDE

    The name of the chemical compound is also known as PT-141

    www.4-men.org/aphrodisiacs/PT141.html

    www.4-men.org/aphrodisiacs/bremelanotide.html

    www.4-men.org/barbie-drug.html

    Sounds good, right ?

    Below is a link with info from the manufacturers - Palatin

    www.palatin.com/products/bremelanotide.asp - Palatin Technologies - The Leader in Melanocortin-based Therapeutics

    The drug has not been granted license since there were concerns over the elevation of blood pressure as a result of its administration. The good news is that that Palatin is still pursueing the development of the drug.

    I am personally prepared to take my chances and i think i will give it a try.

    Guys, seriously, i am so excited. Feeling kind of horny already LOL

    It almost sounds to good to be true but it is nonetheless surely very encouraging and it is definitily quite close to the profile of drug that, i am sure, many of us are looking for. We may not have to wait for ZORAXEL

    I hope it all works fine

    I have sent an email to the the manufacturer enquiring about what stage of development they are at and i am awaiting a response.

    I would suggest you also register your interest.

  2. #2
    buffalobil is offline Junior Member buffalobil is on a distinguished road
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    I dont mean to throw a damper on you enthusiam but I have been using Bremelanotide now for about 9 months. I have experenced many of the results claimed for it but there is a wide variation in response reported by other individuals. It is also not withoug side effects although they are nowhere near as rough as what I got from Viagra.

    I read the article you linked from 4-men.org and it appears it was written before the Phase II trials were halted because of blood pressure spikes in a small percentage of the population.

    It is true that Palatin is planning to restart the phase II trials again but they are going with a SubQ injection delivery instead of a Nasal Spray. They felt that the nasal spray (which require dosing ten times higher than the SubQ injection) led to wide variations in absorbtion and that this was the reason for the BP spikes.

    I have posted links to the Palatins fact sheets and Conference presentations elswhere on this website. I am looking for the reports from the original trials but I have not been able to locate them yet. If I do I will post them here.

  3. #3
    ydrohoos is offline Junior Member ydrohoos is on a distinguished road
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    Quote Originally Posted by buffalobil View Post
    I have experenced many of the results claimed for it but there is a wide variation in response reported by other individuals. It is also not withoug side effects although they are nowhere near as rough as what I got from Viagra.
    Hi buffalobil

    Could you be a little more specific about your experience. For example tell us about what you liked and what you did not like ? Does it help with libido as well as erections ? What about the side effects you have experienced.

    I would also be interested to know where you got hold of it.

  4. #4
    buffalobil is offline Junior Member buffalobil is on a distinguished road
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    Hi Ydrohos,

    Hmmmm, that’s a tall order.

    What I liked:

    It worked,……. and it worked like I expected it to. A lot of erections, but not disconnected from my experiences. By that I mean the erections seemed to be the result of a heightened libido, not like a trimix injection that produced an erection for a couple of hours regardless of what you are doing.

    The heightened libido is much like I experienced in my early teens, where thought of women or visual stimulation (a flash of leg etc.) would produce an immediate and strong erection. I can make the erections go away (so I don’t have the concern of) if I concentrate upon something non sexual for 5 or 10 minutes. But if my girlfriend walks by naked it is back immediately. I also have a lot of sexual daydreams and night dreams when the effect is on and usually a morning erection. In that regard it did not feel like I was taking anything, just more youthful I guess. The erections were a result of the heightened libido and not because of a vascular action and therefore felt very natural. The effect lasts for about 8 hours

    What I don’t like:

    There is a long window between the time you take it and the time enough is absorbed into your system to take effect, somewhere between 4 to 6 hours. The side effects are that you do a lot of yawning and stretching. There are times that I also feel some fatigue and sleepiness, a side effect that no one else seems to report. I believe this sleepiness has more to do with the fact that when I take Bremelanotide, I forgo my daily dose of Dextroamphetamine which I take for ADHD. I also for go any coffee or tea.

    You should also know:

    It is administered by subcutaneous injection (which I don’t mind – it is just under the skin with a very tiny needle. I don’t feel the injection). It is absorbed much slower that when it was a nasal spray which is why the long window to effect. Many people get frightened by the idea of injections and feel they are more dangerous, which would be true if the injections were intravenous. But depositing it just under the skin is no different than bathing the mucous membranes with a spray. The mucous membranes have a lot more blood vessels and are closer to the brain which resulted in a much faster reaction. Unfortunately the spray had to be 10 times stronger and the resulting absorbed dose was very imprecise.

    A strong word of caution and disclaimer:

    The supplier I found on the web sources from one of the labs in China that he has been working with for several years. Bremelanotide has not been approved by the FDA. It is illegal to sell or market bremelanotide (PT-141) and it can only be sold for experimental purposes, not for human consumption. I would not make any recommendations to you about using bremelanotide (PT-141) or who to buy it from. This is an experimental substance and with this comes considerable risk. You and you alone must weight the risks. I made my decision after viewing and conversing with many people on numerous boards for almost a year. That being said you might wish to visit the following site. That board along with this one is the best I have found on the net.

    http://melanotan.org/cgi-bin/yabb/YaBB.pl

  5. #5
    Flavio is offline Senior Member Flavio is on a distinguished road
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    Thanks for posting this guys.

    Bremelanotide shows great promise and could be an excellent solution for psychogenic ED. The only thing I don't like about it is the subcutaneous injection: I hate needles, no matter how small.

    Fresh news on bremelanotide (at palatin.com):


    "August 12, 2009


    PALATIN TECHNOLOGIES, INC. REPORTS POSITIVE BREMELANOTIDE STUDY; IMPROVED SAFETY PROFILE WITH SUBCUTANEOUS ADMINISTRATION


    CRANBURY, NJ – August 12, 2009 – Palatin Technologies, Inc. (NYSE Amex: PTN) today announced the completion of a Phase 1 clinical trial of subcutaneously administered bremelanotide, its melanocortin agonist drug candidate for treatment of male erectile dysfunction (ED) and female sexual dysfunction (FSD). The results demonstrate that with subcutaneous administration consistent therapeutic blood plasma levels can be obtained without blood pressure side effects. Based on the positive results of this study, Palatin has scheduled a meeting with the U.S. Food and Drug Administration to discuss initiation of a Phase 2B study of subcutaneously administered bremelanotide for ED.

    “This study supports our hypothesis that increases in blood pressure and gastrointestinal events seen with intranasally administered bremelanotide were primarily related to high plasma levels in a subset of patients. We believe this was due to variability in drug uptake with intranasal administration,” said Trevor Hallam, Ph.D., Executive Vice President of Research and Development of Palatin. “The switch from intranasal to subcutaneous administration appears to address the blood pressure concerns raised by the FDA. Our next step is to put this data in front of the FDA as we prepare to move bremelanotide back into a Phase 2 study later this year.”

    Key Results
    In all subjects, subcutaneous administration of bremelanotide resulted in consistent and predictable plasma concentrations at levels known from previous studies to improve erectile function. Other key results include:

    •No statistically significant difference in mean changes in blood pressure was seen in subjects receiving bremelanotide compared to placebo.
    •No clinically or statistically significant difference in the range of blood pressure changes was seen in subjects receiving bremelanotide compared to placebo.
    •No subject discontinued participation in the study as a result of protocol stopping rules based on blood pressure changes.
    •No subject discontinued participation in the study due to nausea.
    •No difference in the rate of vomiting observed between subjects receiving bremelanotide compared to placebo (one in each group).

    Study Design
    The two week randomized, double-blind, placebo-controlled Phase 1 study in 54 subjects (27 bremelanotide, 27 placebo) measured blood pressure at baseline and before and after each of 45 doses of bremelanotide or placebo administered subcutaneously. The dose administered was selected to result in a plasma level of bremelanotide known, from previous studies, to be efficacious for improving erectile function. Continuous ambulatory blood pressure data was also collected for the first 48 hours after the initial dose in all subjects.

    Commercial Opportunity
    “We are excited by the commercial opportunity for bremelanotide. About 35% of patients with ED do not respond to approved oral therapies, and with limited treatment options these patients are ideal candidates for subcutaneous bremelanotide,” stated Carl Spana, Ph.D., President and CEO of Palatin. “We have an additional opportunity with FSD, which represents a large market opportunity with no FDA approved drugs.”

    About Bremelanotide
    Bremelanotide, a synthetic peptide developed and solely owned by Palatin, is believed to act through activation of melanocortin receptors in the central nervous system. Intranasal formulations of bremelanotide have been extensively studied, including Phase 2B studies for ED in both non-diabetic and diabetic patients and Phase 2A studies for FSD in both pre- and post-menopausal women.

    About Erectile Dysfunction (ED)
    ED is the consistent inability to attain and maintain an erection sufficient for sexual intercourse. The condition is correlated with increasing age, cardiovascular disease, hypertension, diabetes, hyperlipidemia and smoking. In addition, certain prescription drugs and psychogenic issues may contribute to ED. It is estimated that some degree of ED affects half of all men over the age of 40 and that 150 million men worldwide suffer from ED. Up to 35% of men with ED are non-responsive to standard therapies with phosphodiesterase-5 inhibitors, representing an estimated market of $500 to $600 million per year.

    About Female Sexual Dysfunction (FSD)
    FSD includes four disorders, hypoactive sexual desire disorder, female sexual arousal disorder, dyspareunia and anorgasmia. To establish a diagnosis of FSD, these syndromes must be associated with personal distress, as determined by the affected woman. A February 10, 1999 study published in the Journal of the American Medical Association, titled, “Sexual Dysfunction in the United States: Prevalence and Predictors,” states that approximately 43% of postmenopausal women suffer from some form of FSD. There are no drugs in the United States approved for FSD indications.

    About Palatin Technologies, Inc.
    Palatin Technologies, Inc. is a biopharmaceutical company focused on discovering and developing targeted, receptor-specific small molecule and peptide therapeutics. Palatin's strategy is to develop products and then form marketing collaborations with industry leaders in order to maximize their commercial potential. For additional information regarding Palatin, please visit Palatin Technologies' website at www.palatin.com."

  6. #6
    buffalobil is offline Junior Member buffalobil is on a distinguished road
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    As always, You are the man Flavio. I saw a partial post of those results on another board but not the entire communication. I am delighted with the possibility of such a treatment becoming available, fully certified and thoroughly tested.

    Do you have any sense of how PT141 compares with Zoraxel? While I have overcome my fear and hatred of needles I think something orally dosed and quicker acting is a tremendous benefit for our community in terms of acceptance. Love to hear your thoughts about the two.

    BTW, The Vigamed arrived this weekend. I dosed with the PT141 today and met my girlfriend at 1pm for a little afternoon delight. Figured what the hell, and decided to take 1/2 pill of the Vigamed to see if there was any additional benefit. HOLY MOTHER OF GOD! If I am not careful I will end up like one of those lab rats that screws themselves to death in their cage rather than eat or sleep. My girlfriend left with some difficulty walking convinced I had been possessed by some hyperactive 20 year old.

    And all this from a guy who rated his Psychogenic ED as "Severe". LOL

    For thirty years I have hoped that once before I died I would have the opportunity to experience physical intimacy with the sense of abandonment and pleasure I always imagined was possible. It has arrived and it only can get better with each new development.

    Thanks for the excellent insights on Vigamed.

  7. #7
    Flavio is offline Senior Member Flavio is on a distinguished road
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    I'm glad it worked for you too, Buffalobill.

    VIGAMED is great. It is safer than Viagra and works much faster (it works in only 15-30 minutes, whereas PDE-5 inhibitors may take up to one hour).

    I believe the best way to take VIGAMED is in combination with other ED drugs (apomorphine, PDE-5 inhibitors or, like you said, bremelanotide). I take it with Cialis and there's clearly a synergy between both drugs. I'm very happy with the results and there have been no side effects.

    VIGAMED is a licensed ED drug in South America and there are several studies that show its safety and efficacy. If anyone else is interested in buying it, you can order it online (without a prescription): vasomaxclinic.com

  8. #8
    ydrohoos is offline Junior Member ydrohoos is on a distinguished road
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    Great posting guys.

    >> Buffalobill, i am really glad to hear that things are going so well for you

    I might give this vigamed a try too.

    I have some news on sth else as well. I have started using pramipexole. Find my feedback on the relevant thread.

  9. #9
    Chris_White is offline Junior Member Chris_White is on a distinguished road
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    Sounds like my next vacation needs to include bremelanotide AND VIGAMED. Valuable posts, thank you

  10. #10
    bizebee is offline Junior Member bizebee is on a distinguished road
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    Bremelanotide is the future. But realistically, it is not gong to be in the near future. Politically speaking, I am speaking of the lucrative US Market, it will take decades before it ever gets approved in the US.

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